Fig. 1. Programmed cell death of migrating germ cells in wild-type, p53
and out mutant embryos. Total numbers of PGCs in embryos between
stages 10-14 were determined. In wild-type embryos, germ cell death was
essentially complete by stage 12. In p53 and out embryos,
germ cell death was disrupted. Similar numbers of PGCs were observed with a
gradual loss of germ cells between stages 10 and 14. Error bars represent
s.d.