Fig. 4. Coat color phenotype of Corin mutants. Mice lacking Corin (-/-) exhibit lighter coat-color than corresponding wild type (+/+) on an Agouti background. (A,B) Mice during the first (A) and second (B) hair cycles are shown. (C) Two litters at P16 are shown each containing one a/a (black), one tyrC/tyrC (white) and two A/A with Corin genotypes indicated. (D) Pairs of mice homozygous and heterozygous for a functional agouti allele and wild-type or mutant for Corin are shown with higher magnification views at right. On both Agouti genotypes lack of Corin leads to a lighter coat color and in the absence of Corin, A^W/A^W are lighter than A^W/a.