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Figure 5


Fig. 5. Yellow band extension in Corin mutant zigzag hairs. (A) The longest yellow band found in zigzag hairs lacking Corin (Mut) and the shortest subapical yellow band found in wild-type zigzag hairs (WT) are shown. (B) The approach used to quantify the differences between wild-type and mutant zigzag hairs. The ratio (R) between the length of the yellow band (Y) and the length of the apical segment (Z) was scored and assigned to three categories: R≤0.5 (C,D), 0.5<R≤0.75 (E and F), 0.75<R≤1 (G,H). (C-H) The apical segment of representative hairs in these categories is shown. The tip of each hair is shown in higher magnification in the upper left corner. Both the length of the yellow band and the length of the apical segment vary in both wild-type and mutant mice (compare D with F). (I) The distribution of zigzag hairs in wild-type and mutant mice among the above categories is shown, including the proportion of black versus yellow tips in each category (black vs yellow shading, respectively). All wild-type zigzag hairs end with a black tip (C,E), whereas 70% of mutant zigzag hairs exhibit a yellow tip (D,F,H). The hair population of R≤0.5 with black tips that predominates in the wild type is almost completely absent in mice lacking Corin. The category of 0.75<R≤1 is essentially unique to mice that lack Corin. The P values for R≤0.5, 0.5<R≤0.75 and 0.75<R≤1 are P<0.0001, P=0.0017 and P=0.0002, respectively. Data are mean ± s.d.