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Figure 7


Fig. 7. Reduced numbers of RGCs and RGC axons and cell death in Eomes{Delta}flox/{Delta}flox mice. (A,B) Retinal sections from Eomes+/flox (A) and Eomes{Delta}flox/{Delta}flox (B) retinas at P24 were stained with Hematoxylin and Eosin. (C-F) Immunostaining using anti-NFL antibody on flat-mount Eomes+/flox (C,E) and Eomes{Delta}flox/{Delta}flox (D,F) retinas. NFL staining in the central region of the Eomes{Delta}flox/{Delta}flox retina is less intense and sparser than in the Eomes+/flox control retina (C,D). The difference is more noticeable in the peripheral region (E,F). Many axons are oriented aberrantly (F, arrowheads). OD, optical disc. (G,H) Representative cell death pattern at E18. In Eomes{Delta}flox/{Delta}flox retinas (H), massive cell death can be detected while Eomes+/flox control retinas show little cell death (G). (I,J) Cell death profile from E18 to P24 in the GCL (I), and in the INL and ONL (J).