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Figure 7


Fig. 7. The Shp2 knockout disrupted ERK signaling in lacrimal gland development. (A,B) Loss of Shp2 staining in the conjunctival epithelium of Shp2flox/flox;Le-Cre mutants (broken lines). (C,D) Loss of cell proliferation and lacrimal gland bud in the Shp2 deletion mutant. (E-H) Shp2 knockout disrupted lacrimal gland development at birth and at E14.5 (arrows). (I,J) Deletion of Shp2 resulted in the downregulation of heparan sulfate 10E4 staining in the fornix of the conjunctival epithelium (arrows). (K-R) Phospho-ERK expressions were present in control lacrimal gland buds (arrows), but not in Shp2, Fgfr2 and Ndst1 mutants at the either E12 or E14 (arrowheads). (S-V) ERM expression was lost in the E14.5 Shp2, Fgfr2 and Ndst1 mutants (arrowheads).