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Figure 2


Fig. 2. AML1-ETO transgenic zebrafish possess functional cardiovascular systems. (A) flk1 in situ hybridization of heat-treated wild-type and Tg(hsp:AML1-ETO) embryos harvested at designated stages as indicated. (B) Bright-light and fluorescent images of fli1-EGFP transgenic embryos in wild-type or Tg(hsp:AML1-ETO) background. These embryos have been subjected to the same heat treatment. The arrowhead indicates the site of the accumulated blood cells. (C) Fluorescent microangiography shows that the vasculature is continuous and the site of the accumulated blood cells is connected to the rest of the circulatory system.