Fig. 4. The transcriptional changes in hematopoietic cells of Tg(hsp:AML1-ETO) embryos correlate with the transcriptional changes caused by AML1-ETO expression in human patients and in human cell lines. The embryos used for array #1 were heat shocked two times at 40 and 42°C for one hour each time at 16 and 24 hpf respectively. The blood cells were extracted at 38 hpf. The embryos for arrays #2 and #3 were heat-shocked three times at 40, 42 and 42°C for one hour each time at 16, 24 and 38 hpf respectively. The blood cells were extracted at 40 hpf. The ratios between the signals from Tg(hsp:AML1-ETO) and wild-type samples are shown in the heat map. The corresponding changes in the human studies are indicated in the References column.