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Figure 9


Fig. 9. Trichostatin A suppresses the effects of AML1-ETO in zebrafish embryos. (A-C) DMSO or 0.5 µM TSA was added to Tg(hsp:AML1-ETO) embryos 2 hours before (A,B) or at the end of a 1-hour heat treatment (C) at 38°C at 18 hpf. Tg(hsp:AML1-ETO) embryos that had not been subjected to the heat treatment were used as a control. TSA treatment rescues scl and gata1 downregulation and blocks the accumulation of Mpo+ cells caused by AML1-ETO expression.