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Figure 2


Fig. 2. Three-dimensional reconstruction of the zebrafish otic vesicle (72 hpf) generated from confocal images. (A) The otic vesicle of the wild-type zebrafish has well-formed epithelial pillars (EP) that shape the semicircular canals. The anterior cristae (AC), lateral cristae (LC) and anterior maculae (AM) are indicated. (B) The otic vesicle of an eya4 morphant fish is smaller and misshapened, with fused epithelial pillars and malformed semicircular canals.