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Figure 2


Fig. 2. Dyschondroplasia in adult PtenCo/Co;Col2a1-Cre mice. (A-F) Safranine O staining performed on sections of femur (A-D) and tibia (E,F) from control (A,C,E) or mutant (B,D,F) littermates. Cartilaginous nodules were present in the epiphysis (B, black arrowhead), metaphysis (D, black arrowhead) or diaphysis (F, black arrowhead) of long bones in mutant mice. Cartilaginous nodules resulted in ectopic ossification within cortical bone (D, red arrowhead) or within the bone marrow cavity (F, red arrowhead). Age of bones: P32 in A,B; P58 in C,D; P48 in E,F. Scale bar: 500 µm.