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Figure 2


Fig. 2. OFT alignment and septation defects in Frs2{alpha}cn mutants. H&E staining of E14.5 mouse embryonic heart sections demonstrates overriding aorta (A-C) and double-outlet right ventricle (D-F) defects in Frs2{alpha}cn/Nkx and Frs2{alpha}cn/Mef mutants, and persistent truncus arteriosus defects in the Frs2{alpha}cn/Nkx mutant (G-I). Ao, aorta; DORV, double-outlet right ventricle; LV, left ventricle; OA, overriding aorta; RV, right ventricle; PT, pulmonary trunk; PTA, persistent truncus arteriosus. Black arrows denote OA-associated ventricular septal defects; red arrow denotes the PTA; arrowheads denote DORV.