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Figure 6


Fig. 6. Compromised BMP4 signaling in Frs2{alpha} mutant embryos. (A) Whole-mount in situ hybridization with antisense Bmp4 probe on E9.5 (a-c) or E10.5 (d-f) mouse embryos. Sections (g-l) confirm the decreased Bmp4 expression in the Frs2{alpha}cn OFT and pharyngeal arches. (B) Phosphorylated SMAD1/5/8 expression assessed in E9.5 embryos. High-magnification views of boxed areas in b,d are shown in b',b'',d',d'',as indicated.