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Figure 7


Fig. 7. Aberrant cell migration in the Wnt5a-/- palate. (A-A'') Egfp-expressing mesenchymal cells from the anterior palate, when grafted to the anterior region of an explanted wild-type palatal shelf, exhibit a directional migration towards to the lateral side after 24 hours. Arrows indicate the migrating cells. (B-B'') Egfp-expressing mesenchymal cells from the posterior palate, when grafted to the posterior region of an explanted wild-type palatal shelf, show a directional migration towards the anterior end after 24 hours. (C-C'',D-D'') Directional migration by the Egfp-expressing cells is not observed when these cells are grafted to either the anterior (C-C'') or the posterior (D-D'') palatals shelves from Wnt5a mutants.