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Figure 9


Fig. 9. Tbx22 is specifically downregulated in Mn1-/- mutant palatal shelves at E13.5. (A-C) Tbx22 mRNA is strongly expressed in the middle (B) and posterior (C) palatal mesenchyme, but barely expressed in the anterior (A) palatal mesenchyme in wild-type embryos. (D-F) Tbx22 expression is much reduced in the middle (E) and posterior (F) palatal mesenchyme in the Mn1-/- mutant littermates. Asterisks in B and E indicate the mandibular first molar tooth germ. p, palatal shelf; t, tongue.