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Figure 4


Fig. 4. Ephb1 and Foxd1 are expressed ectopically in the nasal retina of Foxg1-/- embryos. (A-H) Ephb1 in situ hybridization in (A-C) wild-type and (D-H) Foxg1-/- retinas at E16.5; C,G,H show higher magnifications of boxed areas in B,E,F, respectively. In wild-type and in Foxg1-/- retinas, Ephb1 is expressed in peripheral VT RGCs (B,C,F,H). In Foxg1-/- retinas, Ephb1 is expressed ectopically in the nasal retina in (D) dorsal, (E,G) medial and (F,H) ventral sections (indicated by arrows in D, F and boxed area in E). (I-N) Foxd1 in situ hybridization in (I-K) wild-type and (L-N) Foxg1-/- retinas at E16.5. In Foxg1-/- retinas, Foxd1 is expressed ectopically in DN retina. Temporal is towards the top of all panels. Scale bars: 200 µm in A,B,D-F; 100 µm in C,G,H; 400 µm in I-N.