Fig. 8. Cell type-restricted Pcdh- mutation reveals a non-cell-autonomous requirement of -Pcdh function for neuronal survival. (A,B) FoxP2-positive Pax2-negative dI2 interneurons were quantified in both Wnt1-Cre; Pcdh- ^fcon3/fcon3 mice, in which they are mutant, and in Pax2-Cre; Pcdh- ^fcon3/fcon3 mice, in which they are not, at P0. There is no reduction in this population in Wnt1-Cre; Pcdh- ^fcon3/fcon3 mice (A, see C), but a loss of 30% is observed in Pax2-Cre; Pcdh- ^fcon3/fcon3 mice compared with controls (B, see C). (C) Quantitative analysis of ventral interneuron populations in Wnt1-Cre; Pcdh- ^fcon3/fcon3, Pax2-Cre; Pcdh- ^fcon3/fcon3 and Hb9-Cre; Pcdh- ^fcon3/fcon3 spinal cord at P0. Data for mutants are expressed as a percentage of control values. ^*P<0.05; ^**P<0.01. Scale bar: 100 µm.