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Figure 7


Fig. 7. MEFs from Zeb1 mutant mice undergo gene dosage-dependent premature replicative senescence. (A) Effect of Zeb1 mutation on MEF proliferation. (B) Micrographs of cells at early versus later passage numbers. Note the appearance of large, flat senescent-like cells associated with growth arrest. (C) Arrested Zeb1 mutant cells express senescent β-galactosidase (SA-β-Gal; blue X-Gal staining).