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Figure 5


Fig. 5. KBP is required to maintain the speed of axonal outgrowth in the PNS. (A-A'') Lateral views from a time-lapse series of a wild-type embryo with PLLn axons labeled by the Tg(HuC:kaede) transgene at 36 (A), 37 (A') and 38 hpf (A''). Anterior is towards the left and dorsal is towards the top. The arrowheads indicate the posteriormost axons. (B-B'') Lateral views from a time-lapse series of a kbpst23 mutant embryo with PLLn axons labeled by the Tg(HuC:kaede) transgene at 36 (B), 37 (B') and 38 hpf (B''). Anterior is towards the left and dorsal is towards the top. The arrowheads indicate the posteriormost axons. (C-C'') Lateral views from a time-lapse series of a kbpst23 mutant embryo with PLLn axons labeled by the Tg(HuC:kaede) transgene at 54 (C), 55 (C') and 56 hpf (C''). Anterior is towards the left and dorsal is towards the top. The arrowheads indicate the posteriormost axons. (D-D'') Lateral views from a time-lapse series of a kbpst23 mutant embryo with PLLn axons labeled by the Tg(HuC:kaede) transgene at 57 (D), 58 (D') and 60 hpf (D''). Anterior is towards the left and dorsal is towards the top. Arrowheads indicate an axonal swelling that moves backwards along the nerve.