Fig. 6. en PSEs can mediate both positive and negative signals from
many enhancers and silencers. P[en3] is inserted into the capulet
transcription unit. β-Gal activity in proventriculus (PV), brain and wing
disc (WD) is shown. In the PV, loss of both PSE1 and PSE2 leads to ubiquitous
expression of β-gal, whereas in the brain, loss of both PSE1 and PSE2
decreases the expression. PSE2, which is present in
PSE1, seems to
repress transcription in the proventriculus and wing disc, but activates it in
the brain.