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Figure 8


Fig. 8. Both TAp63 and {Delta}Np63 isoforms directly bind to two distinct regions in the CDH3 promoter. (A) ChIP assay in HEK293 cells in which either TAp63{alpha} or TAp63{gamma} was overexpressed. (B) In vivo ChIP assay in HaCaT cells. An antibody against p63 immunoprecipitated both Region 1 and Region 2 of the CDH3 promoter (black arrows) similar to the positive control p21 (gray arrow). The CDH3 coding region was not immunoprecipitated (black arrowhead).