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Figure 7


Fig. 7. Gene expression analysis of the pharyngeal arches in Ednrb-knock-in embryos. (A,B) Whole-mount lacZ staining of E10.5 EdnralacZ/+ (A) and EdnralacZ/B (B) mouse embryos. (C-L) Whole-mount in situ hybridization for Dlx3 (C,D), Dlx5 (E,F), Dlx6 (G,H), Hand2 (I,J) and Goosecoid (K,L) in wild-type (C,E,G,I,K) and EdnraB/B (D,F,H,J,L) embryos at E9.5 (C-H), E10.0 (K,L) or E10.5 (I,J). The expression of Dlx3, Dlx5, Dlx6, Hand2 and Goosecoid was downregulated in EdnraB/B arches.