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Figure 1


Fig. 1. A7.6 group genes mark mesoderm fate and TTF-1 marks endoderm fate in A6.3 lineages. (A) A7.6-specific marker genes Hand-like, FGF8, Delta-like and MyTF are specifically expressed in A7.6 at late 110-cell stage. Delta-like is also expressed in animal blastomeres b7.9, b7.10 next to A7.6. (B) TTF-1 is expressed in endoderm blastomeres. (C,D) Schematic of 32-, 64- and 110-cell embryos showing the mixed lineage of the A6.3 blastomere. At the 32-cell stage, A6.3 is the only endomesoderm blastomere in the Ciona embryo that will give rise to mesoderm (red) and endoderm (yellow) progenies.