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Figure 6


Fig. 6. Injury reverses Runx1{Delta}4/{Delta}4 HFSCs block in quiescence. (A) Schematic of HFSC activation. (B) Back region of {Delta}4 mice post-hair plucking shows hair growth in injured area (arrow). (C) Hematoxylin and Eosin staining of {Delta}4-skin sections collected from wounded and unwounded (opposite) back regions at time points indicated show progression through the hair cycle. (D) Runx1{Delta}4/{Delta}4 injured skin shows proliferating Ki67+ (red, arrows) of CD34+ bulge cells (green). (E) Staining of skin sections 18 days post-wounding shows normal expression of differentiated hair lineage markers. There is a lack of Runx1 staining (performed in serial sections) in {Delta}4 but not in wild-type follicles. (F) Schematic of long-term functional HFSC assay.