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Figure 1


Fig. 1. Distribution of type I BMPRs in the lumbar region of E11.5 mouse spinal cord. (A) BmprIa is expressed throughout the VZ and is absent from the mantle layer, outlined in A and B. (B,C) BmprIb is expressed specifically in the dorsal and intermediate VZ, and in the dorsal-most neurons in the mantle layer (open arrowhead, C). The yellow box in B is shown at higher magnification in C. (D) BmprIb is expressed in an overlapping population of commissural progenitor cells and neurons with that labeled by antibodies against Math1 (open arrowheads, C,D). Scale bars: in A, 50 µm for A,B; in C, 25 µm for C,D.