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Figure 10


Fig. 10. Proposed actions of Ascl1 in oligodendrocyte development. In this model, Ascl1 regulates oligodendrocyte development at multiple steps (thick vertical arrows). At early stages, Ascl1 promotes specification of OLPs from multipotent progenitors (MP). At late embryonic and perinatal periods, Ascl1 regulates the co-expression of Olig2 and Nkx2-2, and subsequently cooperates with them to promote differentiation of myelin+ oligodendrocytes.