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Figure 5


Fig. 5. Inhibition of Wnt5a by dnRor2 affects pulmonary development. (A) Ror2 immunohistochemistry demonstrates expression at E14 in the epithelium (red arrow) and interstitial vessels (red arrowhead) of wild-type lungs. (B) At E18, Ror2 is expressed in the interstitial large muscularized vessel (red arrowhead) and surrounding the luminal epithelium (red arrow and inset). (C,D) H&E staining of RCAS-dnRor2-infected lungs (D) shows an increase in size compared with wild type (C). (E,F) Elderberry bark lectin staining highlights the decrease in endothelium with dnRor2 mis/overexpression.