Fig. 7. Inhibition of fibronectin function rescues the Wnt5a-mis/overexpressed phenotype. (A-F) Lung explants isolated from E8 RCAS-Wnt5a (D,E), RCAS-Wnt3a (C,F) and wild-type (A,B) embryos were grown in culture in absence or in presence of RGDS. RCAS-Wnt5a (D) and wild-type RGDS-treated (B) lung explants showed a reduction in size and a simplification of budding compared with untreated wild-type explants (A). When RGDS was added to Wnt5a mis/overexpressed lung explants (E) an improvement in budding complexity and number was observed. RCAS-Wnt3a explants are hypoplastic (C); incubation in the presence of RGDS (F) has little effect.