Fig. 6. Limb phenotypes of p63^EEC/Dlx combined mutant mice. Skeletal staining of neonatal FL (A-K) and HL (L-V). Wild type is shown in A and L. For the p63^+/EEC limbs, both normal (common phenotype, B,M) and mild ectrodactyly (rare phenotype, C,N) are shown. Dlx5;Dlx6 DKO limbs are shown in H,T. Note that the defects observed in p63^+/EEC (rare) and Dlx5;Dlx6 DKO mice only affect the distal-most portion of the central phalanges. (F,G,R,S) FL and HL of Dlx5^+/-;Dlx6^+/- and Dlx5^-/-;Dlx6^+/- mice. (J,K,U,V) FL and HL of p63^+/EEC;Dlx5^-/-;Dlx6^+/- mice. Note the severe HL defects: missing fingers (black asterisks), bent and fused distal phalanges (black arrows), and altered proximal elements (U,V). Note the defects in the FLs, observed in two out of three cases (K), whereas one was normal (J). FLs and HLs of p63^EEC/EEC animals are also shown for comparison (D,E and P,Q). Digit numbers are indicated (A,L).