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Figure 7


Fig. 7. Defects of the axial skeleton in Myf5-Cre//DTA mice at E18.5. (A-F) Macroscopic views of newborn myogenin-Cre//DTA (A,D), Myf5-Cre//DTA (B,E) and WT (C,F) before (A-C) and after Alzian Blue/Alizarin Red staining (D-F). Enlarged views of the deformed skeleton of Myf5-Cre//DTA mice (G-I). Note the abnormal posture of myogenin-Cre//DTA mice, owing to the absence of skeletal muscles. No primary malformations of the skeleton of myogenin-Cre//DTA mice are apparent.