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Figure 9


Fig. 9. Regulation of the DNA damage response. (A) Treatment of Dictyostelium cells with 30 mM caffeine and 20 mU/ml bleomycin causes a `mitotic catastrophe' phenotype. Two examples (i,ii) are shown. Cells enter an S-like state without division. (B) Response of Ku and DNA-PKcs mutant cells to bleomycin. At 20 mU/ml bleomycin, the Ku and DNA-PKcs mutants are impaired in the recommencement of cell division after checkpoint arrest.