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Figure 1


Fig. 1. Number of DRG neurons and DRG volume are decreased in P0 Runx3-/- mice with no differences in the number of caspase 3+ DRG cells between wild-type and Runx3-/- mice. (A,B) Islet1+ neurons in DRGs of wild-type (A) and Runx3-/- (B) mice at P0. (C,D) Quantitative analysis of the total number of Islet1+ DRG neurons (C) and the DRG volume (D) at the level of Th10 in wild-type (white bars) and Runx3-/- (black bars) mice at E13.5, E16.5 and P0. (E,F) Immunoreactivity (green) of caspase 3 in DRGs of wild-type (E) and Runx3-/- (F) mice at E17.5. The dotted line outlines the DRG. (G) Quantitative analysis of the number of caspase 3+ DRG cells in wild-type (white bars) and Runx3-/- (black bars) mice at E17.5 and P0. Data are shown as mean ±s.e.m.; *P<0.01. Scale bars: 100 µm.