Development -- Nakamura et al. 135 (9): 1703 Figure IG2

(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.

Fig. 2. Loss of expression of parvalbumin in Runx3^-^/^- DRGs during development. (A-F) Photomicrographs indicate parvalbumin (PV) immunoreactivity (brown) at E14.5 (A,D), E18.5 (B,E) and P0 (C,F) in wild-type (A-C) and Runx3^-/- (D-F) DRGs at the level of Th12. (G) Quantification of PV⁺ DRG neurons from E14.5 to P0. The number of PV⁺ neurons in wild-type (white squares) and Runx3^-/- (black squares) mice are shown, and virtually no neurons express PV in Runx3^-/- DRGs through these developmental stages. SC, spinal cord. Data are shown as mean±s.e.m.; ^*P<0.001. Scale bar: 100 µm.