Fig. 3. Transient loss of TrkC expression in Runx3^-/- DRGs during development. (A-J) Photomicrographs showing TrkC immunoreactivity (brown) at E11.5 (A,F), E13.5 (B,G), E14.5 (C,H), E18.5 (D,I) and P0 (E,J) in wild-type (A-E) and Runx3^-/- (F-J) DRGs at the level of Th10. (K) Quantification of TrkC⁺ DRG neurons from E13.5 to P0. The number of TrkC⁺ DRG neurons was consistently smaller in Runx3^-/- (black circles) than in wild type (white circles) mice between E13.5 and P0. (L-O) Immunoreactivity of TrkC in Runx3^+/+; Bax^-/- (L,M) and in Runx3^-/-; Bax^-/- (N,O) DRGs at the level of Th10. The DRGs of L and N are shown at higher magnification in M and O, respectively. TrkC was expressed in Runx3^+/+; Bax^-/- DRG neurons but not in Runx3^-/-; Bax^-/- DRG neurons. Data are shown as mean ±s.e.m.; ^*P<0.05, ^**P<0.01, ^***P<0.001. Scale bars: 100 µm in J and in N for L,N; 50 µm in O for M,O.