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Figure 5


Fig. 5. Differentiation of otic fibrocytes is disturbed in Tbx18KO mice. (A-J) Localization of otic fibrocyte markers by immunohistochemistry (A,B,E-J) and immunofluorescence (C,D) on midmodiolar sections of cochleae of control and Tbx18KO mice at P21. Figures show the lateral wall in the basal turn. Antibodies against proteins specific for fibrocyte subtypes were used as indicated in the figure. Arrow in B marks the loss of strong Otos expression in the region of type IV fibrocytes. (C,D) Overlay of immunofluorescence and differential interference contrast microscopy. Arrowheads in G mark expression in type III fibrocytes. (K) Schematic summary of expression domains and fibrocyte subtype distribution in wild-type and Tbx18KO cochleae. For abbreviations, see Fig. 2.