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Figure 5


Fig. 5. Ectopic expression of pro-apoptotic genes in debcl mutant animals. (A,B) A morphologically normal eye in WT (A) and debcl59 (B). Killing by the RHG proteins is not dependent on debcl function. (C-H) pGMR-rpr (C,D), pGMR-grim4 (E,F) and pGMR-hid (G,H) in the eye showing no effect on the ablated eye phenotype. (I,K) Two different alleles of UAS-Bax1, GMR-Gal4 showing severe ablation of the eye in the WT background. (J,L) This severe eye phenotype is partially restored in a debcl heterozygous background (not shown) and is nearly completely reversed in homozygous debclKO; UAS-Bax1, GMR-Gal4.