Fig. 6. Netrin 1 regulates oligodendrocyte morphology independently of integrins. (A) Application of β1 integrin function-blocking antibody (anti-β1, 2 µM) or a peptide encoding the netrin 1 integrin-binding domain (peptide, 20 µg/ml) failed to block the increase in oligodendrocyte process branching induced by netrin 1 (100 ng/ml). (B) The β1 integrin function-blocking antibody blocks the fibronectin-induced increase in the area (cell spreading) of HEK293T cells, whereas an anti-IgM control antibody does not. A.U., arbitrary units. ^*P<0.05, ^***P<0.0001, versus control. Error bars indicate s.e.m.