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Development, Vol 100, Issue 2 307-311, Copyright © 1987 by Company of Biologists

JOURNAL ARTICLES

The growth rate of sensory nerve fibres in the mammalian embryo

AM Davies
Department of Anatomy, St George's Hospital Medical School, London, UK.

I have used a novel quantitative electron microscopic method to determine the rate at which nerve fibres grow towards their targets during development. The rate of recruitment of nerve fibres to the maxillary nerve of the mouse embryo was determined by counting the number of axon profiles in the nerve sectioned close to its emergence from the trigeminal ganglion at closely staged intervals throughout its early development. The rate of change of fibre number with distance along this nerve was determined by counting the number of axon profiles at intervals along the nerve at stages during the period that fibres are growing to their targets. From these two parameters, both of which were linear functions during the midperiod of fibre recruitment to the nerve, it has been possible to calculate that embryonic sensory nerve fibres grow to their peripheral targets at the surprisingly slow rate of just over 20 micron h-1.


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Development, January 6, 1994; 120(6): 1621 - 1629.
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Regulation of expression of mRNAs encoding the nerve growth factor receptors p75 and trkA in developing sensory neurons
Development, January 11, 1993; 119(3): 635 - 648.
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Different neurotrophins are expressed and act in a developmental sequence to promote the survival of embryonic sensory neurons
Development, January 7, 1993; 118(3): 989 - 1001.
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© The Company of Biologists Ltd 1987