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Development, Vol 101, Issue 1 117-122, Copyright © 1987 by Company of Biologists

JOURNAL ARTICLES

Trans-regulatory functions in the Abdominal-B gene of the bithorax complex

J Casanova and RA White
Centro de Biologia Molecular CSIC-UAM, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain.

We have investigated the functional organization of the Abdominal-B gene in the bithorax complex using the expression of the Ultrabithorax gene as an assay for Abdominal-B trans-regulatory functions. Using Polycomb mutants to relax the normal spatial control of Ultrabithorax expression, we have examined the effects of Abdominal-B mutations on the expression of Ultrabithorax protein products in parasegment 14. The results support the hypothesis that the Abdominal-B gene contains two trans-regulatory functions: the m element active in parasegments 10-13 and the r element acting exclusively in parasegment 14.


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© The Company of Biologists Ltd 1987