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Development, Vol 102, Issue 1 159-174, Copyright © 1988 by Company of Biologists
JOURNAL ARTICLES |
PW Holland and BL Hogan
Laboratory of Molecular Embryology, National Institute for Medical Research, Mill Hill, London, UK.
The mouse Hox 2.1 gene contains a homeobox sequence and is therefore a candidate for a vertebrate gene involved in the control of embryonic patterning or positional specification. To investigate this possibility, we have used in situ hybridization to determine the pattern of Hox 2.1 expression during mouse embryogenesis. At 8.5 days post coitum, Hox 2.1 is expressed at a low level in the posterior neuroectoderm and mesoderm, and in the neuroectoderm of the presumptive hindbrain. At 12.5 days p.c., Hox 2.1 is expressed in an anteroposterior restricted domain extending from the hindbrain throughout the length of the spinal cord, predominantly in the dorsal region. Between 12.5 and 13.5 days p.c. the domain becomes localized to the occipital and cervical regions. We also detect Hox 2.1 RNA in the embryonic lung, stomach, mesonephros and metanephros, as well as in myenteric plexus, dorsal root ganglia and the nodose ganglion, and in mature granulocytes. The embryonic expression of Hox 2.1 in neural tissue is compared with that of Hox 3.1, which also shows anteroposterior restricted domains of gene expression. These patterns of expression are not clearly consistent with Hox 2.1 or Hox 3.1 having roles in segmental patterning. However, the data are consistent with these genes having regulatory roles in anteroposterior positional specification in the neuroectoderm and mesoderm, and suggest that Hox 2.1 may also have functions during organogenesis.
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K M Small and S S Potter Homeotic transformations and limb defects in Hox A11 mutant mice. Genes & Dev., December 1, 1993; 7(12a): 2318 - 2328. [Abstract] [PDF]
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J Whiting, H Marshall, M Cook, R Krumlauf, P W Rigby, D Stott, and R K Allemann Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression. Genes & Dev., November 1, 1991; 5(11): 2048 - 2059. [Abstract] [PDF]
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L M Angerer, G J Dolecki, M L Gagnon, R Lum, G Wang, Q Yang, T Humphreys, and R C Angerer Progressively restricted expression of a homeo box gene within the aboral ectoderm of developing sea urchin embryos. Genes & Dev., March 1, 1989; 3(3): 370 - 383. [Abstract] [PDF]
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P Duprey, K Chowdhury, G R Dressler, R Balling, D Simon, J L Guenet, and P Gruss A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine. Genes & Dev., December 1, 1988; 2(12a): 1647 - 1654. [Abstract] [PDF]
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C A Davis and A L Joyner Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development. Genes & Dev., December 1, 1988; 2(12b): 1736 - 1744. [Abstract] [PDF]
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A Graham, N Papalopulu, J Lorimer, J H McVey, E G Tuddenham, and R Krumlauf Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene. Genes & Dev., November 1, 1988; 2(11): 1424 - 1438. [Abstract] [PDF]
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P W Holland and B L Hogan Expression of homeo box genes during mouse development: a review. Genes & Dev., July 1, 1988; 2(7): 773 - 782. [PDF]
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