|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 103, Issue 3 519-524, Copyright © 1988 by Company of Biologists
JOURNAL ARTICLES |
AE Early and JG Williams
Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, UK.
One important role of DIF, the stalk cell-specific inducer of Dictyostelium, may be to divert cells from the spore cell pathway of differentiation. The D19 gene encodes an mRNA which is highly enriched in prespore over prestalk cells in the migratory slug. We show, using a mutant defective in DIF accumulation, that the concentration of D19, and several other prespore mRNA sequences, decreases in the presence of exogenous DIF. There is evidence that both transcriptional and post-transcriptional controls operate to regulate expression of these genes. We have performed in vitro nuclear transcription and mRNA half-life analyses, and find that DIF acts at the transcriptional level to repress the accumulation of the D19 mRNA.
This article has been cited by other articles:
|
|
 |
|
  T. Keller and C. R. L. Thompson Cell type specificity of a diffusible inducer is determined by a GATA family transcription factor Development, May 1, 2008; 135(9): 1635 - 1645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fukuzawa, N. V. Zhukovskaya, Y. Yamada, T. Araki, and J. G. Williams Regulation of Dictyostelium prestalk-specific gene expression by a SHAQKY family MYB transcription factor Development, May 1, 2006; 133(9): 1715 - 1724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Maruo, H. Sakamoto, N. Iranfar, D. Fuller, T. Morio, H. Urushihara, Y. Tanaka, M. Maeda, and W. F. Loomis Control of Cell Type Proportioning in Dictyostelium discoideum by Differentiation-Inducing Factor as Determined by In Situ Hybridization Eukaryot. Cell, October 1, 2004; 3(5): 1241 - 1248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. L. Thompson, Q. Fu, C. Buhay, R. R. Kay, and G. Shaulsky A bZIP/bRLZ transcription factor required for DIF signaling in Dictyostelium Development, February 1, 2004; 131(3): 513 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Wang and A. Kuspa CulB, a Putative Ubiquitin Ligase Subunit, Regulates Prestalk Cell Differentiation and Morphogenesis in Dictyostelium spp. Eukaryot. Cell, February 1, 2002; 1(1): 126 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Kay and C. R. L. Thompson Cross-induction of cell types in Dictyostelium: evidence that DIF-1 is made by prespore cells Development, December 15, 2001; 128(24): 4959 - 4966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Souza, A. da Silva, and A Kuspa Starvation promotes Dictyostelium development by relieving PufA inhibition of PKA translation through the YakA kinase pathway Development, January 6, 1999; 126(14): 3263 - 3274. [Abstract] [PDF]
|
|
|
|
 |
|
 L. Aubry and R. A. Firtel Spalten, a protein containing Galpha -protein-like and PP2C domains, is essential for cell-type differentiation in Dictyostelium Genes & Dev., May 15, 1998; 12(10): 1525 - 1538. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. R. Kay The Biosynthesis of Differentiation-Inducing Factor, a Chlorinated Signal Molecule Regulating Dictyostelium Development J. Biol. Chem., January 30, 1998; 273(5): 2669 - 2675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Yasukawa, S Mohanty, and R. Firtel Identification and analysis of a gene that is essential for morphogenesis and prespore cell differentiation in Dictyostelium Development, January 7, 1998; 125(14): 2565 - 2576. [Abstract] [PDF]
|
|
|
|
|
|
A. Oohata, M Nakagawa, M Tasaka, and S Fujii A novel prespore-cell-inducing factor in Dictyostelium discoideum induces cell division of prespore cells Development, January 7, 1997; 124(14): 2781 - 2787. [Abstract] [PDF]
|
|
|
|
|
|
M. Niswonger and T. O'Halloran Clathrin heavy chain is required for spore cell but not stalk cell differentiation in Dictyostelium discoideum Development, January 1, 1997; 124(2): 443 - 451. [Abstract] [PDF]
|
|
|
|
|
|
G. M. Souza, J. Hirai, D. P. Mehta, and H. H. Freeze Identification of Two Novel Dictyostelium discoideum Cysteine Proteinases That Carry N-Acetylglucosamine-1-P Modification J. Biol. Chem., December 1, 1995; 270(48): 28938 - 28945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R A Firtel Integration of signaling information in controlling cell-fate decisions in Dictyostelium. Genes & Dev., June 15, 1995; 9(12): 1427 - 1444. [PDF]
|
|
|
|
|
|
J. Powell-Coffman and R. Firtel Characterization of a novel Dictyostelium discoideum prespore-specific gene, PspB, reveals conserved regulatory sequences Development, January 6, 1994; 120(6): 1601 - 1611. [Abstract] [PDF]
|
|
|
|
|
|
L Haberstroh and R A Firtel A spatial gradient of expression of a cAMP-regulated prespore cell-type-specific gene in Dictyostelium. Genes & Dev., April 1, 1990; 4(4): 596 - 612. [Abstract] [PDF]
|
|
