|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Laboratory of Molecular Embryology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
* Present address: Department of Physiology, University of Sydney, New South Wales 2006, Australia
SUMMARY
Small eye (Sey) is a dominant mutation in the mouse affecting the embryonic development of the eyes and nose. In homozygous Sey/Sey embryos, the optic vesicles grow out but there is no lens induction and the nasal pits fail to develop. Scanning electron microscope studies of Sey/Sey embryos show that the maxillary processes develop normally and fuse with ridges of ectoderm in the frontonasal position. In Sey/+ heterozygotes, the vacuolated lens is smaller than normal, and there is folding of the margins of the optic cup and ingrowth of mesodermal cells. Evidence is presented that Sey is not allelic with Coloboma (Cm), another mutation affecting eye development on chromosome 2.
Key words: Small eye (Sey), eye, nose, developmental mutation, optic vesicle, lens placode, nasal placode
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  S. A. Chanas, J. M. Collinson, T. Ramaesh, N. Dora, D. A. Kleinjan, R. E. Hill, and J. D. West Effects of Elevated Pax6 Expression and Genetic Background on Mouse Eye Development Invest. Ophthalmol. Vis. Sci., September 1, 2009; 50(9): 4045 - 4059. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Shaham, A. N. Smith, M. L. Robinson, M. M. Taketo, R. A. Lang, and R. Ashery-Padan Pax6 is essential for lens fiber cell differentiation Development, August 1, 2009; 136(15): 2567 - 2578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Favor, C. J. Gloeckner, A. Neuhauser-Klaus, W. Pretsch, R. Sandulache, S. Saule, and I. Zaus Relationship of Pax6 Activity Levels to the Extent of Eye Development in the Mouse, Mus musculus Genetics, July 1, 2008; 179(3): 1345 - 1355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Sander, A Neubuser, J Kalamaras, H C Ee, G R Martin, and M S German Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes & Dev., July 1, 1997; 11(13): 1662 - 1673. [Abstract] [PDF]
|
|
|
|
|
|
J C Quinn, J D West, and R E Hill Multiple functions for Pax6 in mouse eye and nasal development. Genes & Dev., February 15, 1996; 10(4): 435 - 446. [Abstract] [PDF]
|
|
|
|
|
|
A Stoykova, R Fritsch, C Walther, and P Gruss Forebrain patterning defects in Small eye mutant mice Development, January 11, 1996; 122(11): 3453 - 3465. [Abstract] [PDF]
|
|
|
|
|
|
A T Dudley, K M Lyons, and E J Robertson A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes & Dev., November 15, 1995; 9(22): 2795 - 2807. [Abstract] [PDF]
|
|
|
|
|
|
G Luo, C Hofmann, A L Bronckers, M Sohocki, A Bradley, and G Karsenty BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes & Dev., November 15, 1995; 9(22): 2808 - 2820. [Abstract] [PDF]
|
|
|
|
 |
|
 R Quiring, U Walldorf, U Kloter, and W. Gehring Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans Science, August 5, 1994; 265(5173): 785 - 789. [Abstract] [PDF]
|
|
|
|
|
|
T Glaser, J Lane, and D Housman A mouse model of the aniridia-Wilms tumor deletion syndrome Science, November 9, 1990; 250(4982): 823 - 827. [Abstract] [PDF]
|
|
|
|
|
|
G A Evans Dissecting mouse development with toxigenics. Genes & Dev., March 1, 1989; 3(3): 259 - 263. [PDF]
|
|
