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Development, Vol 105, Issue 2 223-235, Copyright © 1989 by Company of Biologists
JOURNAL ARTICLES |
MH Barcellos-Hoff, J Aggeler, TG Ram and MJ Bissell
Division of Cell and Molecular Biology, Lawrence Berkeley Laboratory, Berkeley, CA 94720.
An essential feature of mammary gland differentiation during pregnancy is the formation of alveoli composed of polarized epithelial cells, which, under the influence of lactogenic hormones, secrete vectorially and sequester milk proteins. Previous culture studies have described either organization of cells polarized towards lumina containing little or no demonstrable tissue-specific protein, or establishment of functional secretory cells exhibiting little or no glandular architecture. In this paper, we report that tissue-specific vectorial secretion coincides with the formation of functional alveoli-like structures by primary mammary epithelial cells cultured on a reconstituted basement membrane matrix (derived from Engelbreth-Holm-Swarm murine tumour). Morphogenesis of these unique three-dimensional structures was initiated by cell-directed remodelling of the exogenous matrix leading to reorganization of cells into matrix-ensheathed aggregates by 24 h after plating. The aggregates subsequently cavitated, so that by day 6 the cells were organized into hollow spheres in which apical cell surfaces faced lumina sealed by tight junctions and basal surfaces were surrounded by a distinct basal lamina. The profiles of proteins secreted into the apical (luminal) and basal (medium) compartments indicated that these alveoli-like structures were capable of an appreciable amount of vectorial secretion. Immunoprecipitation with a broad spectrum milk antiserum showed that more than 80% of caseins were secreted into the lumina, whereas iron-binding proteins (both lactoferrin and transferrin) were present in comparable amounts in each compartment. Thus, these mammary cells established protein targeting pathways directing milk-specific proteins to the luminal compartment. A time course monitoring secretory activity demonstrated that establishment of tissue-specific vectorial secretion and increased total and milk protein secretion coincided with functional alveolar-like multicellular architecture. This culture system is unique among models of epithelial cell polarity in that it demonstrates several aspects of epithelial cell polarization: vectorial secretion, apical junctions, a sequestered compartment and formation of a basal lamina. These lumina-containing structures therefore reproduce the dual role of mammary epithelia to secrete vectorially and to sequester milk proteins. Thus, in addition to maintaining tissue-specific cytodifferentiation and function, a basement membrane promotes the expression of tissue-like morphogenesis.
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|
|
|
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|
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|
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|
|
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|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
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|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
G. M. Edwards, F. H. Wilford, X. Liu, L. Hennighausen, J. Djiane, and C. H. Streuli Regulation of Mammary Differentiation by Extracellular Matrix Involves Protein-tyrosine Phosphatases J. Biol. Chem., April 17, 1998; 273(16): 9495 - 9500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
S Stahl, S Weitzman, and J. Jones The role of laminin-5 and its receptors in mammary epithelial cell branching morphogenesis J. Cell Sci., January 1, 1997; 110(1): 55 - 63. [Abstract] [PDF]
|
|
|
|
|
|
E. E.M. Furlong, N. K. Keon, F. D. Thornton, T. Rein, and F. Martin Expression of a 74-kDa Nuclear Factor 1(NF1) Protein Is Induced in Mouse Mammary Gland Involution. INVOLUTION-ENHANCED OCCUPATION OF A TWIN NF1 BINDING ELEMENT IN THE TESTOSTERONE-REPRESSED PROSTATE MESSAGE-2/CLUSTERIN PROMOTER J. Biol. Chem., November 22, 1996; 271(47): 29688 - 29697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pullan, J. Wilson, A. Metcalfe, G. M. Edwards, N. Goberdhan, J. Tilly, J. A. Hickman, C. Dive, and C. H. Streuli Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium J. Cell Sci., March 1, 1996; 109(3): 631 - 642. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Hathaway and B. Shur Mammary gland morphogenesis is inhibited in transgenic mice that overexpress cell surface beta1,4-galactosyltransferase Development, January 9, 1996; 122(9): 2859 - 2872. [Abstract] [PDF]
|
|
|
|
|
|
L. Lund, J Romer, N Thomasset, H Solberg, C Pyke, M. Bissell, K Dano, and Z Werb Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways Development, January 1, 1996; 122(1): 181 - 193. [Abstract] [PDF]
|
|
|
|
|
|
C. H. Streuli, G. M. Edwards, M. Delcommenne, C. B. A. Whitelaw, T. G. Burdon, C. Schindler, and C. J. Watson Stat5 as a Target for Regulation by Extracellular Matrix J. Biol. Chem., September 15, 1995; 270(37): 21639 - 21644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Saelman, P. Keely, and S. Santoro Loss of MDCK cell alpha 2 beta 1 integrin expression results in reduced cyst formation, failure of hepatocyte growth factor/scatter factor-induced branching morphogenesis, and increased apoptosis J. Cell Sci., January 11, 1995; 108(11): 3531 - 3540. [Abstract] [PDF]
|
|
|
|
|
|
J. Soriano, M. Pepper, T Nakamura, L Orci, and R Montesano Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells J. Cell Sci., January 2, 1995; 108(2): 413 - 430. [Abstract] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
P. Keely, A. Fong, M. Zutter, and S. Santoro Alteration of collagen-dependent adhesion, motility, and morphogenesis by the expression of antisense alpha 2 integrin mRNA in mammary cells J. Cell Sci., January 2, 1995; 108(2): 595 - 607. [Abstract] [PDF]
|
|
|
|
|
|
F Berdichevsky, D Alford, B D'Souza, and J Taylor-Papadimitriou Branching morphogenesis of human mammary epithelial cells in collagen gels J. Cell Sci., January 12, 1994; 107(12): 3557 - 3568. [Abstract] [PDF]
|
|
|
|
|
|
F Sanvito, P. Herrera, J Huarte, A Nichols, R Montesano, L Orci, and J. Vassalli TGF-beta 1 influences the relative development of the exocrine and endocrine pancreas in vitro Development, January 12, 1994; 120(12): 3451 - 3462. [Abstract] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
R.S. Kerbel, J. Rak, H. Kobayashi, M.S. Man, B. St. Croix, and C.H. Graham Multicellular Resistance: A New Paradigm to Explain Aspects of Acquired Drug Resistance of Solid Tumors Cold Spring Harb Symp Quant Biol, January 1, 1994; 59(0): 661 - 672. [Abstract] [PDF]
|
|
|
|
|
|
F Andre, P Filippi, and H Feracci Merosin is synthesized by thyroid cells in primary culture irrespective of cellular organization J. Cell Sci., January 1, 1994; 107(1): 183 - 193. [Abstract] [PDF]
|
|
|
|
|
|
M Umbhauer, J. Riou, J Spring, J. Smith, and J. Boucaut Expression of tenascin mRNA in mesoderm during Xenopus laevis embryogenesis: the potential role of mesoderm patterning in tenascin regionalization Development, January 9, 1992; 116(1): 147 - 157. [Abstract] [PDF]
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D. Shi, J. Feige, J. Riou, D. DeSimone, and J. Boucaut Differential expression and regulation of two distinct fibroblast growth factor receptors during early development of the urodele amphibian Pleurodeles waltl Development, January 9, 1992; 116(1): 261 - 273. [Abstract] [PDF]
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 J.-R. Basque, P. Chailler, and D. Menard Laminins and TGF-beta maintain cell polarity and functionality of human gastric glandular epithelium Am J Physiol Cell Physiol, April 1, 2002; 282(4): C873 - C884. [Abstract] [Full Text] [PDF]
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