|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Journal Articles |
Diacylglycerol (DAG) mediates transmembrane transduction for a wide variety of extracellular signals. Though pattern formation in multicellular organisms is, as a rule, based on intercellular signalling, reports on the participation of DAG in pattern-forming processes are lacking. Here evidence is presented for the involvement of DAG in pattern control in Hydra. Upon daily exposure to 1,2- dioctanoyl-sn-glycerol, wild-type polyps form ectopic heads along the gastric column in a periodic pattern and transform into phenocopies of a multi-headed mutant. The appearance of ectopic head structures is preceded by a (wave-like) increase in the positional value. Long before ectopic tentacles appear in the intact animal and, beginning with the first pretreatment, excised segments progressively fail to regenerate feet, form heads also at their lower end and eventually over the entire segment. DAG is the first physically defined substance found to induce, in hydra, an increase in the positional value and to evoke ectopic head formation.
This article has been cited by other articles:
|
|
 |
|
  M. Broun, L. Gee, B. Reinhardt, and H. R. Bode Formation of the head organizer in hydra involves the canonical Wnt pathway Development, June 15, 2005; 132(12): 2907 - 2916. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. R. Bode The Role of Hox Genes in Axial Patterning in Hydra Integr. Comp. Biol., June 1, 2001; 41(3): 621 - 628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Technau, C. Cramer von Laue, F. Rentzsch, S. Luft, B. Hobmayer, H. R. Bode, and T. W. Holstein Parameters of self-organization in Hydra aggregates PNAS, October 24, 2000; 97(22): 12127 - 12131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Broun, S Sokol, and H. Bode Cngsc, a homologue of goosecoid, participates in the patterning of the head, and is expressed in the organizer region of Hydra Development, January 12, 1999; 126(23): 5245 - 5254. [Abstract] [PDF]
|
|
|
|
|
|
A Grens, H Shimizu, S. Hoffmeister, H. Bode, and T Fujisawa The novel signal peptides, pedibin and Hym-346, lower positional value thereby enhancing foot formation in hydra Development, January 2, 1999; 126(3): 517 - 524. [Abstract] [PDF]
|
|
|
|
|
|
U Technau and H. Bode HyBra1, a Brachyury homologue, acts during head formation in Hydra Development, January 2, 1999; 126(5): 999 - 1010. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Bode The interstitial cell lineage of hydra: a stem cell system that arose early in evolution J. Cell Sci., January 6, 1996; 109(6): 1155 - 1164. [PDF]
|
|
|
|
 |
|
 B. S. Gorman, L. H. Primavera, and D. B. Allison POWPAL: A Program for Estimating Effect Sizes, Statistical Power, and Sample Sizes Educational and Psychological Measurement, October 1, 1995; 55(5): 773 - 776. [Abstract]
|
|
|
|
|
|
B Galliot, M Welschof, O Schuckert, S Hoffmeister, and H. Schaller The cAMP response element binding protein is involved in hydra regeneration Development, January 4, 1995; 121(4): 1205 - 1216. [Abstract] [PDF]
|
|
|
|
|
|
J Weber Novel tools for the study of development, migration and turnover of nematocytes (cnidarian stinging cells) J. Cell Sci., January 1, 1995; 108(1): 403 - 412. [Abstract] [PDF]
|
|
|
|
|
|
R. Weinziger, L. M. Salgado, C. N. David, and T. C. Bosch Ks1, an epithelial cell-specific gene, responds to early signals of head formation in Hydra Development, September 1, 1994; 120(9): 2511 - 2517. [Abstract] [PDF]
|
|
|
|
|
|
M. Shenk, H. Bode, and R. Steele Expression of Cnox-2, a HOM/HOX homeobox gene in hydra, is correlated with axial pattern formation Development, January 2, 1993; 117(2): 657 - 667. [Abstract] [PDF]
|
|
