spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Norris, W. E.
Right arrow Articles by Keynes, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Norris, W. E.
Right arrow Articles by Keynes, R. J.

Development, Vol 105, Issue 3 541-548, Copyright © 1989 by Company of Biologists

JOURNAL ARTICLES

Molecular differences between the rostral and caudal halves of the sclerotome in the chick embryo

WE Norris, CD Stern and RJ Keynes
Department of Human Anatomy, Oxford, UK.

It is known that both neural crest cell migration and motor axon outgrowth in most vertebrate embryos are segmented because of restrictions imposed upon their distribution by the neighbouring sclerotomes, each of which is divided into a rostral and a caudal half. The caudal half does not allow crest migration or axon outgrowth, while the rostral half does. In this paper, we investigate the expression of proteins and glycoproteins in the two halves of the sclerotome of the chick embryo at stages between 20 and 32 pairs of somites by two-dimensional SDS-polyacrylamide gel electrophoresis. We find that the patterns of expression are complex, and that polypeptides and glycoproteins vary both spatially and temporally: of those that are expressed differentially by the sclerotome, some differ quantitatively and others qualitatively. Some macromolecules change their spatial distribution with developmental age, and some appear or disappear as the embryos become older.


This article has been cited by other articles:


Home page
 DevelopmentHome page
K Sharma and E Frank
Sensory axons are guided by local cues in the developing dorsal spinal cord
Development, January 2, 1998; 125(4): 635 - 643.
[Abstract] [PDF]

Home page
 DevelopmentHome page
E. Morin-Kensicki and J. Eisen
Sclerotome development and peripheral nervous system segmentation in embryonic zebrafish
Development, January 1, 1997; 124(1): 159 - 167.
[Abstract] [PDF]

Home page
 DevelopmentHome page
M. A. Nieto, P. Gilardi-Hebenstreit, P. Charnay, and D. G. Wilkinson
A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm
Development, December 1, 1992; 116(4): 1137 - 1150.
[Abstract] [PDF]


© The Company of Biologists Ltd 1989