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Development, Vol 105, Issue 3 569-574 Copyright © 1989 by Company of Biologists

Journal Articles

Ammonia depletion and DIF trigger stalk cell intact Dictyostelium discoideum slugs

M Wang and P Schaap

The differentiation-inducing factor, DIF, was induce stalk cell differentiation in Dictyostelium incubated as submerged monolayers. We investigated the regulates the differentiation of stalk cells in the was found that in migrating or submerged slugs DIF cell differentiation, which is most likely due to the antagonist. Cyclic AMP and ammonia were earlier antagonists in vitro. We show here that ammonia, but an antagonist for DIF-induced stalk cell can induce stalk cell differentiation when ammonia are enzymically depleted. However, depletion of cAMP increase the efficacy of DIF. We propose that the cell differentiation during early culmination may be drop in ammonia levels inside the organism.


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© The Company of Biologists Ltd 1989