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Development, Vol 105, Issue 4 733-737, Copyright © 1989 by Company of Biologists

JOURNAL ARTICLES

An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo

RS Beddington and EJ Robertson
ICRF Developmental Biology Unit, Department of Zoology, Oxford, UK.

Embryonic stem cells (ES) cells were injected into host blastocysts either in groups of 10-15 cells or as single cells in order to test their developmental potential in the developing embryo. The analysis of midgestation chimaeras, by electrophoretic separation of glucose phosphate isomerase (GPI) isozymes, showed that ES cells were capable of colonizing trophectoderm and primitive endoderm derivatives at a low frequency, as well as producing a high rate of chimaerism in tissues of the fetus and extraembryonic mesoderm.


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