|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 106, Issue 1 29-35, Copyright © 1989 by Company of Biologists
JOURNAL ARTICLES |
R Fundele, ML Norris, SC Barton, W Reik and MA Surani
Department of Molecular Embryology, AFRC Institute of Animal Physiology & Genetics Research, Babraham, Cambridge, UK.
The developmental potential of primitive ectoderm cells lacking paternal chromosomes was investigated by examining the distribution of parthenogenetic cells in chimeras. Using GPI-1 allozymes as marker, parthenogenetic cells were detected in most organs and tissues in adult chimeras. However, these cells were under severe selective pressure compared with cells from normal fertilized embryos. In the majority of chimeras, parthenogenetic cells in individual animals were observed in a limited number of tissues and organs and, even in these instances, their contribution was substantially reduced. Nevertheless, parthenogenetic cells were detected more consistently in some organs, especially the brain, heart, kidney and spleen. In contrast, there was apparently a systematic selection against parthenogenetic cells in some tissues, most notably in skeletal muscle, liver and pancreas. These results suggest that paternally derived genes are probably required not only for the development of extraembryonic structures but also for subsequent development of embryonic tissues derived from the primitive ectoderm lineage.
This article has been cited by other articles:
|
|
 |
|
  T. C. Dinger, S. Eckardt, S. W. Choi, G. Camarero, S. Kurosaka, V. Hornich, K. J. McLaughlin, and A. M. Muller Androgenetic Embryonic Stem Cells Form Neural Progenitor Cells In Vivo and In Vitro Stem Cells, June 1, 2008; 26(6): 1474 - 1483. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. LENGERKE, K. KIM, P. LEROU, and G. Q. DALEY Differentiation Potential of Histocompatible Parthenogenetic Embryonic Stem Cells Ann. N.Y. Acad. Sci., June 1, 2007; 1106(1): 209 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Eckardt, N. A. Leu, H. L. Bradley, H. Kato, K. D. Bunting, and K. J. McLaughlin Hematopoietic reconstitution with androgenetic and gynogenetic stem cells Genes & Dev., February 15, 2007; 21(4): 409 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Yang, R. Hao, B. Kessler, G. Brem, E. Wolf, and V. Zakhartchenko Rabbit somatic cell cloning: effects of donor cell type, histone acetylation status and chimeric embryo complementation Reproduction, January 1, 2007; 133(1): 219 - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hikichi, S. Wakayama, E. Mizutani, Y. Takashima, S. Kishigami, N. Van Thuan, H. Ohta, H. Thuy Bui, S.-I. Nishikawa, and T. Wakayama Differentiation Potential of Parthenogenetic Embryonic Stem Cells Is Improved by Nuclear Transfer Stem Cells, January 1, 2007; 25(1): 46 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Nakabayashi, S Makino, S Minagawa, A C Smith, J S Bamforth, P Stanier, M Preece, L Parker-Katiraee, T Paton, M Oshimura, et al. Genomic imprinting of PPP1R9A encoding neurabin I in skeletal muscle and extra-embryonic tissues J. Med. Genet., August 1, 2004; 41(8): 601 - 608. [Full Text] [PDF]
|
|
|
|
 |
|
 L. Hernandez, S. Kozlov, G. Piras, and C. L. Stewart From The Cover: Paternal and maternal genomes confer opposite effects on proliferation, cell-cycle length, senescence, and tumor formation PNAS, November 11, 2003; 100(23): 13344 - 13349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K L Tucker, C Beard, J Dausmann, L Jackson-Grusby, P W Laird, H Lei, E Li, and R Jaenisch Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes. Genes & Dev., April 15, 1996; 10(8): 1008 - 1020. [Abstract] [PDF]
|
|
|
|
|
|
M M Lau, C E Stewart, Z Liu, H Bhatt, P Rotwein, and C L Stewart Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality. Genes & Dev., December 15, 1994; 8(24): 2953 - 2963. [Abstract] [PDF]
|
|
|
|
 |
|
 N. Allen, S. Barton, K Hilton, M. Norris, and M. Surani A functional analysis of imprinting in parthenogenetic embryonic stem cells Development, January 6, 1994; 120(6): 1473 - 1482. [Abstract] [PDF]
|
|
|
|
|
|
E. Jagerbauer, A Fraser, E. Herbst, R Kothary, and R Fundele Parthenogenetic stem cells in postnatal mouse chimeras Development, January 9, 1992; 116(1): 95 - 102. [Abstract] [PDF]
|
|
