spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Menoud, P. A.
Right arrow Articles by Schowing, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Menoud, P. A.
Right arrow Articles by Schowing, J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 106, Issue 4 685-690, Copyright © 1989 by Company of Biologists

JOURNAL ARTICLES

Mouse neural crest cells secrete both urokinase-type and tissue-type plasminogen activators in vitro

PA Menoud, S Debrot and J Schowing
Department of Experimental Embryology and Teratology, University of Fribourg, Switzerland.

Neural tubes of E8-5 day mouse embryos were dissected and cultured in serum substitute-supplemented medium to allow the emigration of neural crest cells. After 48 h of culture the neural tubes were removed. The neural crest cells were then cultured for 12 h in serum-free medium, and their culture supernatant was studied by electrophoresis and zymography. The cultured cells were shown to secrete both urokinase-type and tissue-type plasminogen activators. When the truncal neural tube was divided in four equal segments, the secretion pattern of the two types of plasminogen activators was similar for the cells from the three most anterior segments; cells having migrated from the most caudal one, i.e. consisting of the neural plate, secreted a higher level of urokinase-type plasminogen activator. The secretion in vitro of plasminogen activators by neural crest cells is in accord with the postulated importance of these proteases in cellular migration.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Cancer Res.Home page
Y. Sugiura, L. Ma, B. Sun, H. Shimada, W. E. Laug, R. C. Seeger, and Y. A. DeClerck
The Plasminogen-Plasminogen Activator (PA) System in Neuroblastoma: Role of PA Inhibitor-1 in Metastasis
Cancer Res., March 1, 1999; 59(6): 1327 - 1336.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
P. Carroll, S. Tsirka, W. Richards, M. Frohman, and S Strickland
The mouse tissue plasminogen activator gene 5' flanking region directs appropriate expression in development and a seizure-enhanced response in the CNS
Development, January 11, 1994; 120(11): 3173 - 3183.
[Abstract] [PDF]


© The Company of Biologists Ltd 1989