spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kopczynski, C. C.
Right arrow Articles by Muskavitch, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kopczynski, C. C.
Right arrow Articles by Muskavitch, M. A.

Development, Vol 107, Issue 3 623-636, Copyright © 1989 by Company of Biologists

JOURNAL ARTICLES

Complex spatio-temporal accumulation of alternative transcripts from the neurogenic gene Delta during Drosophila embryogenesis

CC Kopczynski and MA Muskavitch
Department of Biology, Indiana University, Bloomington 47405.

Delta (Dl) function is required for proper specification of epidermal and neural lineages within the neurogenic ectoderm of Drosophila melanogaster. We have determined the spatial accumulation of five Dl transcripts that arise as the result of alternative RNA processing during embryogenesis. We find that these transcripts accumulate in all cells of the neurogenic ectoderm immediately preceding neuroblast segregation, indicating that transcription of Dl does not differ between presumptive neuroblasts and presumptive dermoblasts. Dl transcripts also accumulate transiently in mesodermal and endodermal cells, suggesting that Dl may function in developmental processes in addition to differentiation of the neurogenic ectoderm. We find that three of the Dl transcripts are localized to the base of the nucleus during cellularization. The apparent association of these three transcripts with polysomes suggests that they accumulate within the cytoplasm at the nuclear periphery and is consistent with the hypothesis that Dl encodes multiple translational products.


This article has been cited by other articles:


Home page
 DevelopmentHome page
M. Martin-Bermudo, A Carmena, and F Jimenez
Neurogenic genes control gene expression at the transcriptional level in early neurogenesis and in mesectoderm specification
Development, January 1, 1995; 121(1): 219 - 224.
[Abstract] [PDF]

Home page
 DevelopmentHome page
E Giniger, L. Jan, and Y. Jan
Specifying the path of the intersegmental nerve of the Drosophila embryo: a role for Delta and Notch
Development, January 2, 1993; 117(2): 431 - 440.
[Abstract] [PDF]

Home page
 DevelopmentHome page
P. Kooh, R. Fehon, and M. Muskavitch
Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development
Development, January 2, 1993; 117(2): 493 - 507.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
D Smoller, C Friedel, A Schmid, D Bettler, L Lam, and B Yedvobnick
The Drosophila neurogenic locus mastermind encodes a nuclear protein unusually rich in amino acid homopolymers.
Genes & Dev., October 1, 1990; 4(10): 1688 - 1700.
[Abstract] [PDF]


© The Company of Biologists Ltd 1989