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Development, Vol 107, Issue 4 923-929, Copyright © 1989 by Company of Biologists

JOURNAL ARTICLES

Tissue-specific regulation of junctional communication in the skin of mouse fetuses homozygous for the repeated epilation (Er) mutation

E Kam and JD Pitts
Beatson Institute for Cancer Research, Bearsden, Glasgow, Scotland.

Mouse embryos homozygous for the repeated epilation (Er) gene have abnormally developed skin characterised by hyper-proliferation and incomplete differentiation of the epidermis. In this report, we have studied the patterns of junctional communication in the skin of these mutants to see if the loss of control of proliferation/differentiation is associated with any altered patterns of communication. Using the dye-injection technique we have shown that, compared to normal skin, junctional communication among dermal cells of Er/Er mutants is greatly reduced and the frequency of dermal-epidermal communication is, on the other hand, increased. These results support our previously proposed model, which suggests that selective regulation of junctional communication can be a component of proliferative control in a complex tissue.


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Development, January 9, 1993; 119(1): 85 - 96.
[Abstract] [PDF]


© The Company of Biologists Ltd 1989